Lung Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Lung Cancer, including details on symptoms, smoking, genetics, treatment, causes.

A review of vaccine clinical trials for non-small cell lung cancer.

Nemunaitis J, Nemunaitis J

Mary Crowley Medical Research Center, 60th Floor, 1717 Main St, Dallas, Texas 75201, USA. jnemunaitis@mcmrc.com

Recent evidence suggests that vaccines which enhance tumour antigen recognition may provide clinical benefit to subsets of non-small cell lung cancer patients. In this review, a variety of peptide-, gene- and cell-based clinical vaccine approaches targeting non-small cell lung cancer patients are reviewed. Results consistently demonstrate lack of toxicity. Examples of prolonged stable disease, tumour shrinkage response and survival benefit in comparison with historical and low-dose control groups have been demonstrated. Specific vaccines fulfilling justification for Phase III evaluation based on these results include LBLP25, TGF-beta2 antisense gene vaccine and GVAX.

Published 7 December 2006 in Expert Opin Biol Ther, 7(1): 89-102.
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