Lung Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Lung Cancer, including details on symptoms, smoking, genetics, treatment, causes.

The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: research update.

Maarabouni MM, Williams GT

Institute for Science and Technology in Medicine, Keele University, Keele, Staffs, ST5 5BG, UK. bia19@biol.keele.ac.uk

The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. This review highlights recent evidence that further implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and focuses on the observations that confirm the tumour-suppressor activity of this gene.

Published 1 January 2007 in ScientificWorldJournal, 6: 1705-12.
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