Lung Cancer Research Today is a free monthly online journal that collates and summarizes the latest research about Lung Cancer, including details on symptoms, smoking, genetics, treatment, causes.

Perforated viscus in a patient with non-small cell lung cancer receiving bevacizumab.

Gray J, Murren J, Sharma A, Kelley S, Detterbeck F, Bepler G

Department of Thoracic Oncology, Yale-New Haven Medical Center, New Haven, Connecticut, USA.

Bowel metastasis and perforation in patients with non-small cell lung cancer is rare. Bevacizumab has emerged as a new therapy in the treatment of metastatic non-small cell lung cancer. Bowel perforation associated with its use has been described in colon and ovarian cancers. The exact mechanism by which perforation occurs is under debate, and many theories exist. In this report, we present the first known case of visceral perforation in a patient with metastatic non-small cell lung cancer after treatment with bevacizumab.

Published 4 June 2007 in J Thorac Oncol, 2(6): 571-3.
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