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A small mammal model of tumour implantation, dissemination and growth factor expression after partial hepatectomy.

Aalbers AG, ten Kate M, van Grevenstein WM, Hofland LJ, Wiemer EA, Jeekel J, van Eijck CH

Department of Surgery, Erasmus Medical Centre, University Hospital Rotterdam, The Netherlands.

BACKGROUND: Surgical resection remains the most effective therapy for metastatic colorectal cancer confined to the liver, although the extrahepatic recurrence rate is high. AIM OF THE STUDY: To develop a mammal model in order to investigate by which mechanisms liver surgery affects distant tumour recurrence. METHODS: In this animal study the effect of partial hepatectomy (phX) on the development of tumour noduli in the lungs was evaluated. CC531 rat colon carcinoma cells were inoculated i.v. 24h before, during or 24h after surgery. Rat serum was obtained at different time-points after phX and added to in vitro CC531 cell cultures. Finally, phX was compared with an ileum resection (ilX). RESULTS: phX leads to increased tumour noduli in the lungs, compared to Sham operation (p=0.002), but only when performed directly before the injection of tumour cells and not when performed 24h before or after the inoculation. Comparable results were obtained for ilX. No growth stimulation of tumour cells after incubation with rat serum, obtained at different time-points after phX, could be detected in vitro. CONCLUSION: Not only phX, but also surgery, in general promotes distant tumour recurrence exerting the effect during the early phase of tumour cell adhesion and not during tumour outgrowth.

Published 18 March 2008 in Eur J Surg Oncol, 34(4): 469-75.
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